|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Among miRNA, combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC.
|
30190521 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
<b>Results</b>: After integrated analysis of GEO datasets, we discovered miR-1290 and miR-320d were dysregulated in colorectal adenoma and adenocarcinoma tissues, and circulating miR-1290 and miR-320d in CRC patients were tumor-derived.
|
30662524 |
2019 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our results suggest that exosomal miR-1290 enhances GC cell proliferation and invasion by targeting NKD1 mRNA and downregulating NKD1 expression.
|
31435644 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, the downregulation of miR-1290 inhibited cell metastasis and EMT in OSCC cells.
|
31841213 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Among miRNA, combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC.
|
30190521 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In liver metastasis, miR-143-3p, miR-10b-5p, miR-21-5p, and miR-518f-5p were down-regulated, while miR-122-5p, miR-885-5p, miR-210-3p, miR-130b-5p, miR-1275, miR-139-5p, miR-139-3p, and miR-1290 were up-regulated compared with primary CRC.
|
30604369 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Plasma miR-1290 expression could differentiate adenoma and CRC patients from healthy controls with area under the curve (AUC) of 0.78 and 0.88.
|
30662524 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
Further multivariate analysis showed that serum miR-1290 was an independent risk factor for ESCC.
|
31306104 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
Biomarker
|
disease |
BEFREE |
Circulating miR-1290 and miR-320d as Novel Diagnostic Biomarkers of Human Colorectal Cancer.
|
30662524 |
2019 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Plasma miR-1290 expression could differentiate adenoma and CRC patients from healthy controls with area under the curve (AUC) of 0.78 and 0.88.
|
30662524 |
2019 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, Cox regression analysis based on the 5-year overall survival and disease-free survival revealed that miR-1290 status was a significant prognostic factor for patients with oral squamous cell carcinoma (hazard ratio = 0.169, p = 0.008, and hazard ratio = 0.186, p = 0.008, respectively).
|
30887897 |
2019 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
And upregulation of miR-1290 was associated with clinicopathological characteristics and poor prognosis in OSCC patients.
|
31841213 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Here, we designed this study to explore the potential effect of miR-1290 on tumorigenesis of OSCC.
|
31841213 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Results</b>: After integrated analysis of GEO datasets, we discovered miR-1290 and miR-320d were dysregulated in colorectal adenoma and adenocarcinoma tissues, and circulating miR-1290 and miR-320d in CRC patients were tumor-derived.
|
30662524 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggest that exosomal miR-1290 enhances GC cell proliferation and invasion by targeting NKD1 mRNA and downregulating NKD1 expression.
|
31435644 |
2019 |
|
Sepsis of the newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma miR-1290 is a novel and specific biomarker that can effectively differentiate NEC cases from neonatal sepsis. miR-1290 facilitates neonatologists to confidently and timely reach a decision for early transfer of sick infants with NEC from community-based hospitals to tertiary surgical centers.
|
30529132 |
2019 |
|
Necrotizing Enterocolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma miR-1290 Is a Novel and Specific Biomarker for Early Diagnosis of Necrotizing Enterocolitis-Biomarker Discovery with Prospective Cohort Evaluation.
|
30529132 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggest that exosomal miR-1290 enhances GC cell proliferation and invasion by targeting NKD1 mRNA and downregulating NKD1 expression.
|
31435644 |
2019 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients.
|
31191687 |
2019 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated kinase (ERK) pathway upon IAV infection and is associated with increased viral titers in human cells and ferret animal models. miR-1290 was observed to target and reduce expression of the host vimentin gene.
|
31173947 |
2019 |
|
Bacterial sepsis of newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma miR-1290 is a novel and specific biomarker that can effectively differentiate NEC cases from neonatal sepsis. miR-1290 facilitates neonatologists to confidently and timely reach a decision for early transfer of sick infants with NEC from community-based hospitals to tertiary surgical centers.
|
30529132 |
2019 |
|
Necrotizing enterocolitis in fetus OR newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma miR-1290 is a novel and specific biomarker that can effectively differentiate NEC cases from neonatal sepsis. miR-1290 facilitates neonatologists to confidently and timely reach a decision for early transfer of sick infants with NEC from community-based hospitals to tertiary surgical centers.
|
30529132 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The gliomas orthotopic implantation model of nude mice was established to investigate the influence of miR-1290 and LHX6 on tumor growth.
|
29226322 |
2018 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Higher miR-1290 expression levels positively associated with lymph node metastasis and advanced tumor stage.
|
29275213 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Furthermore, miR-1290 promoted tumor growth, invasion and metastasis <i>in vivo</i>. miR-1290 downregulated suppressor of cytokine signaling 4 (SOCS4) at both the mRNA and protein levels by targeting SOCS4.
|
29552286 |
2018 |